Fig. 6

HP1β is enriched within genes in pluripotent cells. a ChIP-Seq enrichment scores for HP1β in the indicated genomic regions. HP1β is highly enriched within exons (*** p < 0.0001, * p < 0.005, permutation test). Note promoter depletion. UTR untranslated region. b Average HP1β distribution (over all genes) around the transcription start site (TSS). c HP1β distribution within an average intron. Introns are overall enriched for HP1β but depleted when compared with exons. d HP1β distribution within an average exon. e HP1β is localized in gene bodies and exons. Examples of HP1β ChIP-Seq signal in genes and exons. RefSeq gene annotation is shown in the top row; below, HP1β ChIP-Seq read signals are shown in red and input read signals are shown in blue. MACS peaks are shown in the bottom row