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Table 1 Top 10 GWAS SNPs which are associated with senDMP signature ordered by absolute chi-squared statistic

From: The senescent methylome and its relationship with cancer, ageing and germline genetic variation in humans

SNP ID

CHR

Position

Gene

RAL

Trait

Cor

Stat

rs10496584

2

123126479

Intergenic

A

Lentiform nucleus volume

0.885

−424

rs4848768

2

123141545

Intergenic

B

Lentiform nucleus volume

−0.865

−403

rs12716852

16

78188738

WWOX

A

Pulmonary function

0.896

−375

rs17041

6

108853493

LACE1

B

Obesity-related traits

0.927

369

rs7944584

11

47336320

MADD

A

Fasting glucose-related traits (interaction with BMI)

0.909

−354

rs2989476

1

61059259

NFIA

A

Bipolar disorder

−0.888

338

rs966423

2

218310340

DIRC3

A

Thyroid cancer

0.869

−338

rs4527850

8

134196849

WISP1

A

Type 2 diabetes

0.839

−327

rs4432842

5

57172078

Intergenic

B

Birth weight

0.810

326

rs2479106

9

126525212

NR

B

Polycystic ovary syndrome

0.860

326

  1. Cor: Pearson’s correlation coefficient between the SNP and the senDMPs; RAL: risk allele for the SNP; Stat: the directional chi-squared statistic