Fig. 2
From: Chromatin states and nuclear organization in development — a view from the nuclear lamina
Histone modifications regulate perinuclear sequestration. A model of known and suggested histone tail modifications involved in heterochromatin anchoring at the nuclear envelope. The deposition of histones carrying H3K9me1 or H3K9me2 could be sufficient to ensure localization at the nuclear envelope according to work with the worm Caenorhabditis elegans [74]. Potential methyl readers that might contribute to anchoring include the lamin B receptor (LBR) in mammals and a C. elegans chromodomain protein (CEC-x) in worms. Readers of the H3K9me3 modification that ensure silencing include worm homologs of heterochromatin protein 1 (HP1) and LIN-61. Other factors implicated in tissue-specific gene repression and sequestration include cKROX and HDAC3, or an unknown reader of H4K20me3. See text for further details