Conserved non-coding networks in Steinernema and Caenorhabditis.
a A hierarchically clustered heat map of 30 derived regulatory motifs and the GO terms that the target genes of these motifs are enriched in. Only motif-GO term associations that are shared between S. carpocapsae and C. elegans are shown. p-values depicted are from C. elegans associations. Colored arrows point to single GO term or groups of GO terms that belong to the four developmental categories shown. b A network of conserved S. carpocapsae and C. elegans motif-target gene associations related to neurogenesis GO terms. Only nodes for motifs and downstream genes with degrees ≥5 are shown in the network. c A network of conserved S. carpocapsae and C. elegans motif-target gene associations related to muscle GO terms. Only nodes for motifs and downstream genes with degrees ≥5 are shown in the network. d
zag-1 gene model in S. carpocapsae and C. elegans showing conserved motifs, and well as conserved regulatory modules (clusters of conserved motifs). Sequence conservation tracks are displayed below each gene model. Associations between zag-1 and motifs are highlighted in red in the neurogenesis network. GO Gene Ontology