Fig. 6

Comparison of the methylation levels and the Hi-C compartment signal for chromosome 14. The figure displays data from 36.4 to 69.8 Mb on chromosome 14 at 100-kb resolution. a The first eigenvector from the HiC-IMR90-2014 dataset. b Average methylation on the beta scale for ten selected samples from the 450 k-fibroblast dataset; each sample is a line and divergent colors are used to distinguish the different levels of methylation in the different samples. c The first eigenvector from the HiC-EBV-2014 data. d Like (b), but for ten samples from the 450 k-EBV dataset; the samples from the two datasets are unrelated. On (d) we depict four different bins. Scatterplots between methylation values in different bins across all samples in the dataset are shown in (e–g). e For two bins in the closed compartment. g For one bin in the open and one bin in the closed compartment. g For two bins in the open compartment. The figure shows that samples have roughly the same ranking inside each closed compartment