Fig. 1

Overview of chromatin interaction hubs. a Definition of chromatin interaction hubs. Chromatin anchors are ranked based on the frequency of significant interactions and classified into four group: Hubs, Median, Low, None. b DNA sequence of hubs. The average PhastCons conservation score and GC Content ratio (left-y-axis) within chromatin anchors is normalized against the genomic background. TSS proximity (right-y-axis) is represented by the distance to the closest TSS. c Enrichment of the super-enhancers in IMR90 cells. Chromatin anchors in each group are further divided into two subgroups are according the distance to their closest TSS, Proximal (<100 kb) and Distal (> = 100 kb). d Functional enrichment analysis using GREAT. e Enrichment of the SNPs in GWAS catalog. Chromatin anchors in each group are further divided into two subgroups according the distance to their closest TSS, Proximal (<100 kb) and Distal (> = 100 kb)