Mousea
| Experiments and replicatesb
| Down-regulated genesc
| Up-regulated genesc
|
---|
P10 | P21 | P10 | P21 | P10 | P21 |
---|
WT | 3 | 3 | NA | NA | NA | NA |
E168d2/d2
| 3 | Not tested | 425 | NA | 248 | NA |
R90W/W
| 3 | Not tested | 195 | NA | 70 | NA |
E168d2/+
| 3 | 3 | 136 | 150 | 61 | 43 |
E168d2neo/+
| 3 | 3 | 85 | 83 | 38 | 19 |
R90W/+
| 3 | 3 | 20 | 27 | 12 | 27 |
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a All mutant mice were backcrossed to C57BL/6 J (WT) control for >10 generations and genotyped for common variants [21]
-
b Numbers represent biological replicates. Each replicate contains four pooled retinas from a male and female pair
-
c Numbers represent transcripts significantly altered (FC ≥ 2, FDR ≤ 0.05) relative to WT control
-
NA not applicable