Fig. 6

Correlation heatmaps of EE gene expression with DNAm levels of individual genomic loci across different cancer types. Heatmaps of correlation Fisher Z-statistics between the DNAm levels of ~140,000 genomic regions (~100,000 open sea plus ~40,000 CGI) and mRNA expression of the regulator, as indicated. For UHRF1 and WHSC1, regions have been ranked from positive to negative correlations as determined in breast cancer, whereas for CBX7, regions have been ranked from negative to positive correlations. The same ranking is then used to depict the correlation statistics in the other cancer types. Above the heatmaps we give the P values corresponding to the Spearman rank correlation coefficient between the ranking in breast cancer and the ranking in every other cancer type