Fig. 4

Pan-cancer-wide correlation analysis between EE expression and DNA methylation. a Heatmaps of Pearson correlation coefficients between mRNA expression of EE genes and the HyperZ or HypoZ indices, as assessed across cancers from ten different TCGA cancer types (BRCA breast cancer, BLCA bladder cancer, COAD colon adenomacarcinoma, HNSC head and neck squamous carcinoma, KIRC kidney renal carcinoma, LIHC liver hepatocellular carcinoma, LSCC lung squamous cell carcinoma, LUAD lung adenomacarcinoma, THCA thyroid cancer, UCEC uterine cervix endometrial carcinoma). Only EE genes exhibiting significant and directionally consistent correlations in at least six of the ten cancer types are shown. The subset of EE genes which also show significant and directionally consistent differential expression changes between normal and cancer in at least eight of the ten cancer types are colored, with red indicating overexpression in cancer, green underexpression. Those shown in black indicate that these were not consistently differentially expressed across the ten cancer types. b Correlation network meta-analysis (across all ten cancers) of the main epigenetic oncogenes and tumor suppressors which are associated with HyperZ or HypoZ