Fig. 1

Enrichment of cancer cells in the PDX. a Schematic representation of experiments. A portion of a LUAD patient tumor (Pt tumor) was propagated by xenograft transplantation in humanized immunocompromised female NOG mice. PDX cells (PDX) were dissociated and cultured from xenograft tumors, and subjected to drug screening. b Estimated cancer cell fraction in Pt tumor and PDX cells. The fraction was quantified by histopathological examination (striped bar), or estimated based on computational analysis using expression profiles (blue) or WES data (green). c Estimated degree of normalized copy number changes in log2 ratio to matched peripheral blood for deletion (green) or amplification (red) are indicated. Representative sites of copy number changes in LUAD are labeled on the right side. d Distribution of variant allele frequencies (VAF) of the non-synonymous somatic mutations that overlap between Pt tumor and PDX cells. Color-scaled density map indicates the number of mutations