Figure 5
From: Domain atrophy creates rare cases of functional partial protein domains
N-terminal end-bounded atrophy: AMP-binding domain. Comparison of (A) the atrophied N-terminal AMP-binding domain of B. cenocepacia phenylacetate-CoA ligase (PDB: 2Y27, green) and (B) reference structure, Alcaligenes sp 4-chlorobenzoyl CoA ligase (PDB: 3CW9, blue) bound to AMP (gold) and 4-Chlorophenacyl-coenzyme A (magenta). (C) Superposition of the N-terminal domains shows the atrophied region of 2Y27, which corresponds to the first sub-domain of 3CW9 (orange, residues 1-150). The residues of the first sub-domain, except Arg87 (yellow), have minimal interactions with ligands AMP (gold) or 4-Chlorophenacyl-coenzyme A. (D) Homo-dimeric complex of atrophied B. cenocepacia phenylacetate-CoA ligase forms an arrangement, which at the interface is structurally similar to the first-sub domain.