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Figure 6 | Genome Biology

Figure 6

From: Single-cell analysis of lung adenocarcinoma cell lines reveals diverse expression patterns of individual cells invoked by a molecular target drug treatment

Figure 6

Gene expression patterns in a given cell. (A) Individual single cells of different cell lines are plotted according to expression levels of the EGFR, MYC and RET genes. The color key for the cell lines is shown to the right. (B) Results of a similar analysis as in (A) but for LC2/ad and LC2/ad-R cells treated with or vandetanib or not. Notable expression changes observed for LC2/ad-R cells are indicated by pink circles. (C) Hierarchal clustering analyses were conducted using the indicated groups of genes. Clusters of individual cells are represented in the left margin of the heat maps. The color key for the cells is shown to the right. (D) Results of a similar analysis as (C) but for Cancer Gene Census genes. The color key for the cell lines is shown to the right of the heat maps. (E) Results of the principle component analysis for Cancer Gene Census genes in LC2/ad (left panel) and LC2/ad-R (right panel) cells. Color keys for the cell lines are shown to the right.

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