Methylation-dependent SOX9 expression mediates invasion in human melanoma cells and is a negative prognostic factor in advanced melanoma

Table 2 Multivariate cox regression on metastatic melanoma patients

Covariate	HR	Lower 95%	Upper 95%	p-value
SOX9 (SOX9 low = 0, SOX9 high =1)	2.343	1.402	3.915	0.001***
Age	0.995	0.977	1.103	0.59
Gender (female = 0, male =1)	0.756	0.457	1.25	0.276
T0 (used as reference)
T1	0.431	0.117	1.598	0.208
T2	0.943	0.416	2.138	0.888
T3	1.022	0.489	2.132	0.955
T4	2.145	1.01	4.557	0.047*
N0 (used as reference)
N1	1.673	0.813	3.446	0.162
N2	1.365	0.673	2.771	0.388
N3	1.322	0.574	3.044	0.512
M0 (used as reference)
M1	2.023	0.672	6.09	0.21
Lymph Node (used as reference)
Regional Cutaneous or Subcutaneous Metastasis	0.844	0.452	1.577	0.595
Distant Metastasis	1.83	0.957	3.499	0.068

SOX9 expression, age, gender, TNM stage, and tumor location were evaluated in a multivariate cox regression model. Hazard ratio (HR) and the 95% CIs are displayed for each covariate.
*P <0.05.
***P <0.001.

ISSN: 1474-760X