Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring

Table 1 Assessment of ChrY gene copy number among B6-ChrY consomic strains

	*Slx* ^b	*Sly*	*Ssty1*	*Ssty2*	*Srsy*	*Rbmy*	*Rbm31y*
C57BL/6 J BACs^a		126	85	221	197	30	2
C57BL/6 J	26 ± 1	128 ± 6	85 ± 4	238 ± 49	199 ± 13	30 ± 1	2 ± 0
B6-ChrY^PWD	29 ± 2	150 ± 6	70 ± 4	375 ± 33	219 ± 17	29 ± 1	1 ± 0
B6-ChrY^A/J	26 ± 1	136 ± 9	102 ± 4	287 ± 91	226 ± 7	31 ± 1	2 ± 0
B6-ChrY¹²⁹	29 ± 2	155 ± 9	90 ± 5	620 ± 87	225 ± 21	26 ± 1	2 ± 0
B6-ChrY^MA	26 ± 1	45 ± 2	510 ± 8	2381 ± 249	248 ± 18	8 ± 0	1 ± 0
B6-ChrY^BUB	27 ± 2	19 ± 1	290 ± 25	1041 ± 158	143 ± 15	11 ± 0	1 ± 0
B6-ChrY^ST	24 ± 1	20 ± 1	272 ± 10	366 ± 49	154 ± 5	10 ± 1	1 ± 0
B6-ChrY^LEWES	26 ± 1	24 ± 1	310 ± 39	87 ± 7	69 ± 5	9 ± 1	1 ± 0
B6-ChrY^MET	28 ± 2	70 ± 5	91 ± 3	183 ± 16	91 ± 9	30 ± 1	2 ± 0
B6-ChrY^AKR	27 ± 1	36 ± 4	340 ± 64	237 ± 9	118 ± 13	7 ± 0	1 ± 0
B6-ChrY^SWR	26 ± 1	23 ± 1	259 ± 8	580 ± 54	174 ± 10	11 ± 1	1 ± 0
B6-ChrY^WSB	27 ± 1	41 ± 4	411 ± 59	787 ± 93	130 ± 14	7 ± 0	1 ± 0
B6-ChrY^SJL	27 ± 1	16 ± 1	350 ± 56	1289 ± 194	171 ± 20	11 ± 0	1 ± 0
B6-ChrY^RF	28 ± 1	33 ± 1	407 ± 18	1503 ± 101	134 ± 10	9 ± 1	1 ± 0

^aCopy number of ChrY genes determined by sequencing from C57BL/6 J BAC libraries [29]. This number was assigned to a B6 calibrator sample and used to calculate CNV for the ChrY consomic strains.
^bEstimated copy number of 25 was assigned to a B6 calibrator sample to calculate CNV in Slx among female offspring of B6-ChrY consomic strains [29].
Numbers represent the mean copy number ± standard error of the mean rounded to the nearest integer. n = 3 to 5 mice per strain.

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