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Figure 5 | Genome Biology

Figure 5

From: Copy number variation in Y chromosome multicopy genes is linked to a paternal parent-of-origin effect on CNS autoimmune disease in female offspring

Figure 5

B6-ChrY consomic strains inheriting a M. mus domesticus ChrY exhibit phenotypes associated with X-Y intragenomic conflict. (A) Mean sex ratio for each strain was calculated by determining the male:female (M:F) sex ratio across all litters born to a single dam, then averaging the sex ratio across all dams tested. n ≥ 10. Significance of differences determined by one-way ANOVA. (B) Mean litter size for each strain was calculated by averaging the number of offspring across all litters born to one dam, then averaging litter size across all dams tested (n ≥ 10). Significance of differences determined by one-way ANOVA. (C) The percentage of sperm head abnormalities for each strain. The image depicts a normal sperm head on the left followed by representative pictures of abnormal sperm heads seen across the strains. Significance of differences determined by one-way ANOVA followed by Dunnett’s multiple comparisons test. P ≤ 0.05 for all domesticus B6-ChrY consomic strains. Data are represented as the mean ± standard deviation. n ≥ 5 mice per strain.

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