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Table 1 Summary details of the four analysis cohorts

From: DNA methylation age of blood predicts all-cause mortality in later life

  LBC1921 LBC1936 FHS NAS
N 446 920 2,635 657
ndeaths 292 106 238 226
Time to death (years) 7.2 (3.5) 4.4 (2.2) 6.0 (1.2) 10.5 (3.3)
Age (years) 79.1 (0.6) 69.5 (0.8) 66.3 (8.9) 72.9 (6.9)
Sex (male) 176 (40%) 465 (51%) 1200 (46%) 657 (100%)
Hannum methylation age (years) 85.0 (5.6) 75.8 (5.0) 68.2 (8.7) 77.6 (6.7)
Hannum Δage (years) 5.9 (5.6) 6.2 (5.1) 1.9 (4.8) 4.6 (4.8)
Hannum median error (years) 5.5 6.4 1.9 4.6
Horvath methylation age (years) 73.7 (6.2) 66.0 (5.8) 65.7 (8.3) 73.5 (7.4)
Horvath Δage (years) −5.4 (6.3) −3.6 (5.8) −0.6 (5.2) 0.6 (5.8)
Horvath median error (years) 6.0 4.7 0.69 3.4
Tissue sample Whole blood Whole blood Whole blood Buffy coat
Methylation array Illumina 450 k Illumina 450 k Illumina 450 k Illumina 450 k
  1. FHS: Framingham Heart Study, LBC: Lothian Birth Cohort, NAS: Normative Aging Study.