An analysis of DNA methylation in human adipose tissue reveals differential modification of obesity genes before and after gastric bypass and weight loss

Table 4 Differentially methylated CpG sites in omentum

Ilumina probe ID	Gene symbol	Chromosome and map position (build 37)	∆beta	T statistic	P value
cg04627183	PDE7B	6: 136365249	0.070	13.5	2.0 × 10⁻⁹
cg08351331	LBP	20: 36975083	0.058	12.1	8.5 × 10⁻⁹
cg08514779	-	13: 112076555	0.073	11.9	1.1 × 10⁻⁸
cg16546882	-	7: 54731606	0.037	10.8	3.7 × 10⁻⁸
cg01907005	PLIN4	19: 4517804	0.043	10.5	5.0 × 10⁻⁸
cg00031105	RXRB	6: 33166117	0.069	10.5	5.2 × 10⁻⁸
cg06673130	CPLX1	4:778924	−0.072	−10.5	5.2 × 10⁻⁸
cg18736186	GALK2	15: 49462118	0.054	10.4	5.6 × 10⁻⁸
cg19758873	-	4: 49462118	0.059	10.2	7.6 × 10⁻⁸
cg06579248	MYO1C	17: 1375968	0.034	10.1	8.0 × 10⁻⁸
cg26790198	CSTL1	20: 23419120	0.041	10.1	8.7 × 10⁻⁸
cg15420634	SLC9A3	5: 485359	0.041	10.1	8.8 × 10⁻⁸
cg01127300	-	22: 38614796	0.112	10.0	9.3 × 10⁻⁸
cg04344695	CA12	15: 63658391	0.091	10.0	9.7 × 10⁻⁸
cg12157387	PARD3B	2: 206347777	0.083	10.0	9.7 × 10⁻⁸

All CpG sites passing Bonferroni correction are shown. A positive value for ∆beta indicates hypermethylation before weight loss in comparison to after weight loss, and a negative value indicates hypomethylation. Gene symbol ‘-’ represents an intergenic region to which no known genes map.

ISSN: 1474-760X