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Figure 5 | Genome Biology

Figure 5

From: Deep sequencing of multiple regions of glial tumors reveals spatial heterogeneity for mutations in clinically relevant genes

Figure 5

Heterogeneity of PDGFRA amplification in BI06. (A) Copy number estimates based on smMIP probe data. PDGFRA amplification (labeled) occurs in region A with only mild amplification in region B and no clear detectable amplification in regions C, D or E. (B) Results from Taqman qPCR targeting PDGFRA performed in quadruplicate. Region X refers to a region of brain tissue grossly uninvolved by tumor. PDGFRA amplification occurs in region A (approximately four-fold amplification) with only mild amplification in regions B, C, D and E. Error bars represent the mean +/- one standard deviation from quadruplicate values.

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Genome Biology

ISSN: 1474-760X

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