Lighter: fast and memory-efficient sequencing error correction without counting

Table 1 Accuracy measures for datasets simulated with Mason with various sequencing depths and error rates

Coverage		35×		70×		140×
Error rate		1 %	3 %	1 %	3 %	1 %	3 %
α for Lighter		0.2	0.2	0.1	0.1	0.05	0.05
	Quake	89.68	48.77	89.64	48.82	89.59	48.78
	SOAPec	57.71	38.00	57.57	37.71	57.09	36.76
Recall	Musket	93.75	92.62	93.73	92.64	93.73	92.63
	Bless	99.81	99.33	99.82	99.58	99.82	99.58
	Lighter	99.87	98.53	99.84	98.72	99.86	98.78
	Quake	99.99	99.99	99.99	99.99	99.99	99.99
	SOAPec	99.99	100.00	99.99	99.99	99.99	99.99
Precision	Musket	99.99	99.93	99.99	99.93	99.99	99.93
	Bless	99.73	98.86	99.73	99.35	99.72	99.36
	Lighter	99.98	99.96	99.98	99.96	99.98	99.96
	Quake	94.55	65.56	94.54	65.61	94.51	65.57
	SOAPec	73.18	55.07	73.07	54.77	72.68	53.75
F score	Musket	96.77	96.14	96.76	96.15	96.76	96.15
	Bless	99.77	99.09	99.77	99.47	99.77	99.47
	Lighter	99.93	99.24	99.91	99.33	99.92	99.36
	Quake	89.67	48.76	89.64	48.82	89.59	48.78
	SOAPec	57.70	38.00	57.57	37.71	57.09	36.75
Gain	Musket	93.74	92.56	93.72	92.58	93.72	92.57
	Bless	99.54	98.19	99.54	98.93	99.54	98.94
	Lighter	99.85	98.49	99.81	98.68	99.84	98.73
	Quake	17	17	17	17	17	17
	SOAPec	17	17	17	17	17	17
k	Musket	23	19	23	19	23	19
	Bless	31	23	31	23	31	23
	Lighter	23	19	23	19	23	19

ISSN: 1474-760X