Loci with and without significant epiallele shift. Epiallele pattern proportion change on non-eloci (a, Δ = 0, chr1: 234367244-234367265, SLC35F3 exon), non-eloci (b, Δ = -20, chr1: 103319658-103319682, downstream of COL11A1 gene), drift eloci (c, model II, ? = -80, chr16: 330195-330217, epipolymorphism at diagnosis: 0.27, at relapse: 0.62, increased by 0. 35, ARHGDIG promoter) and selection eloci (d, model I, ? = -114 , epipolymorphism at diagnosis:0.68, at relapse: 0.15, decreased by 0. 53, chr10: 109674359- 109674402, SORCS1 distal upstream). Model I is defined as eloci with increased epigenetic tumor heterogeneity measured by epipolymorphism. Model II is defined as eloci with decreased epigenetic tumor heterogeneity measured by epipolymorphism.