Figure 9

Weighted gene co-expression network of miRNAs in response to Nod and Myc symbiotic factors. (a) Different colors (blue, green and orange) represent each regulatory module identified by the WGCNA analysis. The smallest nodes are miRNAs non-responsive to the treatment with the signaling molecules. The biggest nodes are miRNAs responsive to one or both signals. The shape of the node indicates the differential expression pattern: circles represent miRNAs responsive to Nod factor; diamonds represent miRNAs responsive to Myc factor; squares represent miRNAs responsive to both molecules. Names for miRNAs already described in miRBase V20 or new putative variants of known miRNA families are labeled, the latter including the suffix '-like'. Nodes without any label correspond to new miRNAs identified in this study. (b) Biological processes associated with the three regulatory modules of miRNA co-expression networks as inferred from the analysis of the Gene Ontology terms of the predicted targets per module. Each radar-plot depicts the repartition of the different biological processes (percentage) for each of the three modules of the network (that is, blue, green and orange). Each branch in the radar plots corresponds to the same biological process.