Figure 1
From: Deep sequencing of the X chromosome reveals the proliferation history of colorectal adenomas
Evolutionary model of tumor clonal expansion. (A) Expansion of a monoclonal adenoma represented as a rooted binary tree [2]. Colored dots indicate somatic mutations that progressively occur during tumor development and are inherited by the surviving progeny. (B) Tree recapitulating the proliferation as inferred from the mutation profile. The combination of nodes in the tree reveals the occurrence of selection and cell death during tumor proliferation.