SUMO processing and SUMO deconjugation activities of human SENP family members. Schematic representation of SENP processing and deconjugation activities towards distinct SUMO paralogs. The left part summarizes the activities of SENPs in maturation/processing of human SUMO paralogs. The maturation process removes the amino acids carboxy-terminal to a di-glycine (GG) motif (sequences are given for the human SUMO variants). The middle part describes the specificity for deconjugating distinct SUMO forms from substrates (isopeptidase activity). The right part highlights the activity of SENP6 and SENP7 for editing lysine (K)-linked SUMO2/3 chains. These chains are predominantly formed by SUMO2 and SUMO3 and are preferentially linked via K11. The figure tries to integrate data from biochemical in vitro experiments and cell-based assays.