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Figure 7 | Genome Biology

Figure 7

From: A simple metric of promoter architecture robustly predicts expression breadth of human genes suggesting that most transcription factors are positive regulators

Figure 7

Expression pattern divergence between paralogs correlated with promoter divergence. This figure consists of six parts identified as ( a ) - ( f ). Expression pattern divergence between duplicates was measured with either ( a ) Pearson’s correlation; ( b ) the Kendall rank correlation coefficient; or ( c ) Spearman's rank correlation coefficient. Promoter divergence was measured using Jaccard index (JI). The correlation disappeared when duplicate pairs were randomized ( d-e-f ) proving that it was well defined and specific. The red line signified the linear model for the smoother line, while the blue line signified the non-linear model. This figure suggests that the correlation between the breadth of expression and the number of transcription factor binding sites persisted if alternative non-parametric measures of expression distances between paralogs were used. Details of the correlations were given in Table 8.

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