Figure 5
From: Characteristic bimodal profiles of RNA polymerase II at thousands of active mammalian promoters
PolII and RNA-seq model fits are correlated. (a, b) Examples of two imprecise TSSs for (a) Dtd1 and (b) Cbwd1, showing the sum of Gaussians model fit (red) to PolII signal and rectangular function model fit (blue) for the RNA signal. (c) Correlation between the shifts defined by PolII and RNA-seq models for strict (black: 731 genes with R2=0.56, P<2.2×10-16) and very strict (red: 183 genes with R2=0.72, P<2.2×10-16) values of the fitting-quality criterion and TATA genes (blue). Dtd1 and Cbwd1 are highlighted with a light blue and a green circle, respectively. (d) Averaged profiles of PolII occupancy near TSS with no shift, RNA-seq model shift or PolII model shift to align first peak positions (731 genes). a.u., arbitrary units.