Figure 5

Comparison of editing frequencies in samples from cancerous and healthy tissues. (A) Each point represents the estimated editing frequency of a single miRNA in a matched sample (cancer and control) from the same patient. Cases where a significant difference in editing was detected between the two conditions (χ²-test with Benjamini-Hochberg correction) are highlighted in red. (B) Summary of the significant cases in (A). Sample identifiers consist of a letter giving the cancer type and a number that refers to the patient identifier in the original study. Blue bars represent significant downregulation of miRNA editing in cancer samples, with the top of the bar corresponding to the editing frequency in the control sample and the bottom of the bar corresponding to the editing frequency in the cancer sample. Red bars represent significant editing upregulation, with the bottom of the bar corresponding to the editing frequency in the control sample and the top of the bar corresponding to the editing frequency in the cancer sample.