Changes in miRNA editing frequencies during primate postnatal development and aging. (A) Spearman correlation coefficients for miRNA editing frequencies and age in human and macaque (see main text for details). The respective correlations for ADAR and ADARB1 mRNA expression levels are indicated as squares. Cases where the correlation coefficients were significant in both species are highlighted in red. (B) Editing frequencies for the six significant miRNAs (see (A)) in samples from different ages, with younger individuals on the left and older on the right. (C) Distribution of correlation coefficients for age and expression levels, calculated for mRNAs predicted to be targeted either by edited or unedited miRNAs. If expression is independent of age, the expected correlation coefficient is 0, as indicated by the dotted line. Statistical significance is indicated by double (0.001 < P < 0.01) or triple (P < 0.001) asterisks.