Conserved editing and 5′ length variation of miR-411. (A) As a result of A-to-I editing (here represented as A-to-G) and alternative 5′ cleavage, the miR-411 precursor gives rise to four variants with distinct seed sequences. The short, unedited variant is the annotated form. (B) Venn diagram of the predicted targets for each miR-411 variant. Targets were predicted with TargetScan release 6.0  and were required to be present in at least 10 species, including human, macaque and mouse. (C) Relative abundance of the four miR-411 variants in (from top to bottom) human, macaque and mouse, when considering reads from all five tissues together.