Skip to main content
Figure 6 | Genome Biology

Figure 6

From: Distinct and overlapping control of 5-methylcytosine and 5-hydroxymethylcytosine by the TET proteins in human cancer cells

Figure 6

Links between aberrant cancer methylation and TET function. (A) Genes susceptible to hypermethylation in cancer (n = 1,009) [58] showed significant overlap with those that lose 5hmC within gene bodies (that is, exons and introns) in each of the siTET-treated conditions: 45.7% of hypermethylated genes overlap 5hmC loss in siTET1-treated cells (P = 0.0255); 34.3% of hypermethylated genes overlap 5hmC loss in siTET2-treated cells (P = 0.0002); 31.0% of hypermethylated genes overlap 5hmC loss in siTET3-treated cells (P = 0.0082; siTET3 not shown). (B) Ontology analysis of genes susceptible to promoter hypermethylation that also lose 5hmC in siTET-treated cells.

Back to article page

Genome Biology

ISSN: 1474-760X

Contact us