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Table 4 Gene expression and methylation correlation in tDMRs

From: DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns

Gene region

Neg PCCsa

Pos PCCsb

PCCs < -0.5c

PCCs >0.5d

Totale

Global

2,288

1,332

749

372

3,620

 

63.2%

36.8%

20.7%

10.3%

 

Promoter + CGI

489

134

76

37

623

 

78.5%

21.5%

12.2%

5.9%

 

5’UTR

264

279

57

77

543

 

48.6%

51.4%

10.5%

14.2%

 

1st exon

212

217

41

61

429

 

49.4%

50.6%

9.6%

14.2%

 

Body

1,148

737

377

224

1,885

 

60.9%

39.1%

20.0%

11.9%

 

3’UTR

190

209

51

62

399

 

47.6%

52.4%

12.8%

15.5%

 

Shores

1,275

745

423

202

2,020

 

63.1%

36.9%

20.9%

10.0%

 

Shelves

445

269

169

82

714

 

62.3%

37.7%

23.7%

11.5%

 
  1. aNegative Pearson Correlation coefficients (PCCs).
  2. bPositive PCCs.
  3. cStrong negative PCCs, smaller than -0.5.
  4. dStrong positive PCCs, larger than 0.5.
  5. eTotal number of tDMRs in named category.