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Table 2 GO analysis with hypomethylated tDMRs

From: DNA methylome profiling of human tissues identifies global and tissue-specific methylation patterns

Tissue

GO term

Genes (n)

P value

Adipose tissue (abdominal, subcutaneous)

Lipid homeostasis

5

0.0096

 

White fat cell differentiation

3

0.0172

 

Fat cell differentiation

4

0.0532

Artery (coronary, splenic)

Blood vessel morphogenesis

12

3.24E-04

 

Angiogenesis

10

4.25E-04

 

Blood vessel development

13

4.60E-04

Aorta (thoracic, abdominal)

Cardiac muscle tissue development

11

5.91E-04

 

Muscle organ development

24

8.21E-04

 

Striated muscle tissue development

16

9.72E-04

Bone, joint cartilage

Chondrocyte differentiation

3

0.0067

 

Cartilage development

4

0.0253

 

Skeletal system development

7

0.0553

Bone marrow (red, yellow)

Cell activation

41

5.07E-07

 

Leukocyte activation

33

7.98E-06

 

Immune response

62

1.97E-05

Lymph node

-

  

Tonsils

Immune response

59

7.00E-06

 

Regulation of T cell activation

17

4.38E-05

 

Defense response

50

7.22E-05

Gastric mucosa

Regulation of pH

2

0.0530

 

Monovalent inorganic cation homeostasis

2

0.0677

Bladder

Muscle contraction

14

0.0034

 

Excretion

7

0.0266

 

Secretion

17

0.0379

Gall bladder

Negative regulation of granulocyte differentiation

2

0.0417

 

Negative regulation of immune system process

3

0.0496

 

Regulation of granulocyte differentiation

2

0.0519

Medulla oblongata

Homophilic cell adhesion

15

8.78E-06

 

Cell-cell adhesion

18

5.00E-04

 

Cell adhesion

25

0.0151

Ischiatic nerve

Filopodium assembly

5

0.0023

 

Regulation of action potential in neuron

10

0.0036

 

Negative regulation of neurogenesis

7

0.0074