Methylation-expression relationships in genomic context. Schematic of significant methylation-expression relationships for (A-D) the four HOX clusters, and (E,F) genes TBX1 and TBX3. Gold and blue lines link the TSS of the gene and the CpG probes correlated to that gene’s expression, with gold indicating negative correlation and blue indicating positive correlation. Red and blue blocks above indicate the presence of DHS or H3K4me3 marks in at least one of five ENCODE fibroblast cell lines. Where a domain boundary from Dixon et al. was found, the domains are indicated with distinct colors.