Figure 2

Example data tracks for IMR-90 chromosome 7. (A) WGBS methylome (black) per CpG-site and per 100-bp bin (purple) as obtained by Lister and others [40]. CpG density (light blue), and read counts for SssI-treated DNA (blue) and IMR-90 cells (green) obtained by MBD-seq based on 100-bp non-overlapping bins are shown. Methylation estimates for BayMeth (red) and Batman (orange) are provided. (B) Detailed posterior information for BayMeth and Batman for four specific bins of panel A (denoted a, b, c and d). For BayMeth, the posterior marginals together with 95% HPD credible intervals (shaded gray) are shown. The posterior samples obtained by Batman are plotted as histograms. For both approaches the posterior mean is indicated (red dashed line) together with the true WGBS-derived methylation estimate (blue dashed line). chr, chromosome; kb, kilobase; WGBS, whole genome bisulfite sequencing.