Figure 2

ZFP36 binds to mRNAs encoding regulatory proteins. (A) Gene ontology enrichment analysis of genes with ZFP36 binding sites ranked and shaded from red (lowest) to green (highest) by Bonferroni corrected P values (< 0.05) from Panther DB. (B) Distribution of ZFP36 binding sites (red) and ELAVL1 binding sites (purple) from PAR-CLIP data for immune-relevant RBPs. The genomic span is indicated for each gene and these spans vary greatly. (C-F) Visualization of individual ZFP36 binding sites with the T-to-C conversion density estimate (red line) and read counts (grey) within the ZFP36, ZFP36L1, ZFP36L2 and ELAVL1 3′ UTRs. chr, chromosome; PAR-CLIP, photoactivatable ribonucleoside cross-linking and immunoprecipitation; RBP, RNA-binding protein; UTR, untranslated region.