Relative importance of chromatin regulatory factors in tumorigenesis across sites. (A) Histograms of the fraction of samples with 0 (green) or at least one (red) likely driver CRF with PAMs in each site. (B) Boxplots representing the distribution of fraction of CRFs with PAMs with respect to all FM-biased genes with PAMs in each sample (CF ratios) of samples from each site with at least one mutation in a CRF (red fraction in panel A). (C) Boxplots representing the distribution of CF ratios of samples from each of the three projects focused on brain tumors. CRF, chromatin regulatory factors; DKFZ, German Cancer Research Center; JHU, Johns Hopkins University; TCGA, The Cancer Genome Atlas.