Figure 3

FM bias, mutation frequencies and mutually exclusivity of chromatin regulatory factors as part of complexes. (A) Left heat-map shows the P value of FM bias analysis for all CRFs and for each complex. Right heat-map shows the number of samples with PAMs in the complex and the color indicates the mutation frequency (number of samples with PAMs divided by number of samples of this cancer type analyzed). (B) Heat-map of samples and genes of each complex, PAMs are represented as green cells in the heat-map. Tumor samples from each site have headers of the corresponding colors. Samples and genes in the heat-map are ordered based on mutually exclusive alterations within each site using Gitools built-in function for this purpose. Number of samples with PAMs in the gene (N) and the mutation frequency (Freq) of the gene in whole dataset are shown at the right of each heat-map. Gene names in bold indicated that the gene is one of the 34 detected as candidate drivers. PAM, protein-affecting mutations.