Sustained-input switches for transcription factors and microRNAs are central building blocks of eukaryotic gene circuits

Table 1 Graph size, percentage of failed FANMOD edge switches, and motif count standard deviations for the 12 biological networks considered in the analysis.^a

FNR (TF binding sites)	deltaG (miRNA targets), n	Nodes, n	Edges, n	FANMOD failed switches, %	Standard deviation
					WaRSwap count, n	FANMOD count, n
0.2	60	27,289	463,239	96	1,241,486	3,638
	70	27,281	462,242	96	18,154	3,626
	80	27,257	461,146	96	17,512	3,426
0.4	60	25,835	255,485	89	713,360	3,739
	70	25,791	254,488	89	10,484	3,726
	80	25,734	253,392	90	10,244	3,588
0.6	60	21,034	107,776	73	255,576	1,791
	70	20,883	106,779	73	3,751	1,759
	80	20,653	105,681	74	3,658	1,637
0.8	60	12,366	36,301	57	58,094	434
	70	12,009	35,303	58	841	420
	80	11,506	34,203	59	825	392

Abbreviations: FANMOD, Fast Network Motif Detection; FNR, False-negative rate, miRNA, MicroRNA; TF, Transcription factor; WaRSwap, Weighted-and-Reverse-Swap.
^aFor each biological network, there were 2,500 random subgraphs generated using the WaRSwap and FANMOD algorithms.

ISSN: 1474-760X