Table 1 Performance of the algorithms on simulated data with one tumor population (n = 2)
From: THetA: inferring intra-tumor heterogeneity from high-throughput DNA sequencing data
| Â | % correct C | Copy number error (median) | Purity error (median) | |||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|
k | THetA | ASCAT | CNAnorm | ABSOLUTE | THetA | ASCAT | CNAnorm | ABSOLUTE | THetA | ASCAT | CNAnorm | ABSOLUTE |
3 | 100.0 | 85.0 | 40.0 | 70.0 | 0.0 | 0.0 | 0.103 | 0.000 | 0.004 | 0.040 | 0.068 | 0.010 |
4 | 90.0 | 55.0 | 8.3 | 50.0 | 0.0 | 0.0 | 0.163 | 0.013 | 0.004 | 0.037 | 0.064 | 0.010 |
5 | 85.0 | 50.0 | 6.7 | 15.0 | 0.0 | 0.013 | 0.185 | 0.160 | 0.004 | 0.062 | 0.038 | 0.075 |
6 | 55.0 | 40.0 | 0.0 | 15.0 | 0.0 | 0.026 | 0.291 | 0.433 | 0.006 | 0.063 | 0.066 | 0.157 |
7 | 30.0 | 15.0 | 0.0 | 10.0 | 0.031 | 0.036 | 0.445 | 0.471 | 0.005 | 0.069 | 0.108 | 0.149 |