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Table 4 Results of the over-representation analysis of the predicted target genes of brain-miR-112.

From: A blood based 12-miRNA signature of Alzheimer disease patients

Subcategory Subcategory alternative name Expected Observed Pvalue (FDR) Target genes AD BD DEP PD SCHIZ Multiple sclerosis
Neurogenesis GO:0022008 119.612 31 0.000284421 ONECUT2 ANK3 CACNB3 CDK6 CELSR3 FGFR2 MEF2A NFIB PICALM PLAG1 PLXNA1 PSD4 PTPRR RAB11A RPS6KA4 SIX4 COL4A4 DFNB31 DISC1 SRF STX3 ADCY1 CDKN1C CNP ENAH HOXC10 LIF LRP6 ROCK1 RPS6KA3 TFAP2A -- DISC1 -- -- DISC1 --
Neuron differentiation GO:0030182 103.937 27 0.000801251 ONECUT2 ANK3 CACNB3 CELSR3 FGFR2 MEF2A NFIB PICALM PLXNA1 PSD4 PTPRR RAB11A RPS6KA4 COL4A4 DFNB31 SRF STX3 ADCY1 CDKN1C CNP ENAH HOXC10 LIF LRP6 ROCK1 RPS6KA3 TFAP2A -- -- -- -- -- --
Neuron development GO:0048666 845.125 23 0.00159317 ONECUT2 ANK3 CACNB3 CELSR3 FGFR2 MEF2A NFIB PICALM PLXNA1 RAB11A RPS6KA4 COL4A4 DFNB31 SRF STX3 ADCY1 CDKN1C CNP ENAH LIF ROCK1 RPS6KA3 TFAP2A -- -- -- -- -- --
Nervous system development GO:0007399 184.019 37 0.00268227 ONECUT2 ANK3 CACNB3 CDK6 CELSR3 FGFR2 MEF2A NFIB PICALM PLAG1 PLXNA1 PSD4 PTPRR RAB11A RPS6KA4 SEMA5B SIX4 COL4A4 DFNB31 DISC1 FGF1 SRF STX3 SULF1 ADCY1 ARHGEF15 CDKN1C CNP ENAH HOXC10 LIF LPHN1 LRP6 MEN1 ROCK1 RPS6KA3 TFAP2A FGF1 DISC1 -- -- DISC1 --
Neuron projection development GO:0031175 736.077 19 0.00946322 ANK3 CACNB3 CELSR3 FGFR2 MEF2A NFIB PICALM PLXNA1 RAB11A RPS6KA4 COL4A4 SRF STX3 ADCY1 CNP ENAH LIF ROCK1 RPS6KA3 -- -- -- -- -- --
Neuron projection GO:0043005 633.844 16 0.0262424 ALOX5 ANK3 MYLK2 NFIB SLC38A7 DFNB31 DISC1 FRMPD4 GRIA4 SLC6A1 STX3 AAK1 ALDOC ARHGEF15 BACE1 LPHN1 BACE1 DISC1 -- -- DISC1 GRIA4 --
Neurotransmitter:sodium symporter activity GO:0005328 0.215825 3 0.0330004 SLC6A20 SLC6A1 SLC6A6 -- -- -- -- -- --
Neuron projection morphogenesis GO:0048812 624.756 15 0.0391162 ANK3 CACNB3 CELSR3 FGFR2 MEF2A NFIB PICALM PLXNA1 RPS6KA4 COL4A4 ADCY1 CNP ENAH ROCK1 RPS6KA3 -- -- -- -- -- --
Neurotransmitter transporter activity GO:0005326 0.272621 3 0.0412241 SLC6A20 SLC6A1 SLC6A6 -- -- -- -- -- --
Neuroblast division GO:0055057 0.0795144 2 0.0412241 FGFR2 LRP6 -- -- -- -- -- --
Forebrain neuroblast division GO:0021873 0.0795144 2 0.0412241 FGFR2 LRP6 -- -- -- -- -- --
Generation of neurons GO:0048699 112.797 31 0.000188727 ONECUT2 ANK3 CACNB3 CDK6 CELSR3 FGFR2 MEF2A NFIB PICALM PLAG1 PLXNA1 PSD4 PTPRR RAB11A RPS6KA4 SIX4 COL4A4 DFNB31 DISC1 SRF STX3 ADCY1 CDKN1C CNP ENAH HOXC10 LIF LRP6 ROCK1 RPS6KA3 TFAP2A -- DISC1 -- -- DISC1 --
Cell morphogenesis involved in neuron differentiation GO:0048667 616.805 15 0.0366659 ANK3 CACNB3 CELSR3 FGFR2 MEF2A NFIB PICALM PLXNA1 RPS6KA4 COL4A4 ADCY1 CNP ENAH ROCK1 RPS6KA3 -- -- -- -- -- --
  1. This table lists interesting Gene Ontology (GO) subcategories with Pvalues <0.05 and FDR adjustment related to nervous system development.
  2. AD: Alzheimer disease; BP: bipolar disorder; DEP: major depression; PD, Parkinson's disease; SCHIZ: schizophrenia