Table 4 Results of the over-representation analysis of the predicted target genes of brain-miR-112.
From: A blood based 12-miRNA signature of Alzheimer disease patients
Subcategory | Subcategory alternative name | Expected | Observed | Pvalue (FDR) | Target genes | AD | BD | DEP | PD | SCHIZ | Multiple sclerosis |
|---|---|---|---|---|---|---|---|---|---|---|---|
Neurogenesis | GO:0022008 | 119.612 | 31 | 0.000284421 | ONECUT2 ANK3 CACNB3 CDK6 CELSR3 FGFR2 MEF2A NFIB PICALM PLAG1 PLXNA1 PSD4 PTPRR RAB11A RPS6KA4 SIX4 COL4A4 DFNB31 DISC1 SRF STX3 ADCY1 CDKN1C CNP ENAH HOXC10 LIF LRP6 ROCK1 RPS6KA3 TFAP2A | -- | DISC1 | -- | -- | DISC1 | -- |
Neuron differentiation | GO:0030182 | 103.937 | 27 | 0.000801251 | ONECUT2 ANK3 CACNB3 CELSR3 FGFR2 MEF2A NFIB PICALM PLXNA1 PSD4 PTPRR RAB11A RPS6KA4 COL4A4 DFNB31 SRF STX3 ADCY1 CDKN1C CNP ENAH HOXC10 LIF LRP6 ROCK1 RPS6KA3 TFAP2A | -- | -- | -- | -- | -- | -- |
Neuron development | GO:0048666 | 845.125 | 23 | 0.00159317 | ONECUT2 ANK3 CACNB3 CELSR3 FGFR2 MEF2A NFIB PICALM PLXNA1 RAB11A RPS6KA4 COL4A4 DFNB31 SRF STX3 ADCY1 CDKN1C CNP ENAH LIF ROCK1 RPS6KA3 TFAP2A | -- | -- | -- | -- | -- | -- |
Nervous system development | GO:0007399 | 184.019 | 37 | 0.00268227 | ONECUT2 ANK3 CACNB3 CDK6 CELSR3 FGFR2 MEF2A NFIB PICALM PLAG1 PLXNA1 PSD4 PTPRR RAB11A RPS6KA4 SEMA5B SIX4 COL4A4 DFNB31 DISC1 FGF1 SRF STX3 SULF1 ADCY1 ARHGEF15 CDKN1C CNP ENAH HOXC10 LIF LPHN1 LRP6 MEN1 ROCK1 RPS6KA3 TFAP2A | FGF1 | DISC1 | -- | -- | DISC1 | -- |
Neuron projection development | GO:0031175 | 736.077 | 19 | 0.00946322 | ANK3 CACNB3 CELSR3 FGFR2 MEF2A NFIB PICALM PLXNA1 RAB11A RPS6KA4 COL4A4 SRF STX3 ADCY1 CNP ENAH LIF ROCK1 RPS6KA3 | -- | -- | -- | -- | -- | -- |
Neuron projection | GO:0043005 | 633.844 | 16 | 0.0262424 | ALOX5 ANK3 MYLK2 NFIB SLC38A7 DFNB31 DISC1 FRMPD4 GRIA4 SLC6A1 STX3 AAK1 ALDOC ARHGEF15 BACE1 LPHN1 | BACE1 | DISC1 | -- | -- | DISC1 GRIA4 | -- |
Neurotransmitter:sodium symporter activity | GO:0005328 | 0.215825 | 3 | 0.0330004 | SLC6A20 SLC6A1 SLC6A6 | -- | -- | -- | -- | -- | -- |
Neuron projection morphogenesis | GO:0048812 | 624.756 | 15 | 0.0391162 | ANK3 CACNB3 CELSR3 FGFR2 MEF2A NFIB PICALM PLXNA1 RPS6KA4 COL4A4 ADCY1 CNP ENAH ROCK1 RPS6KA3 | -- | -- | -- | -- | -- | -- |
Neurotransmitter transporter activity | GO:0005326 | 0.272621 | 3 | 0.0412241 | SLC6A20 SLC6A1 SLC6A6 | -- | -- | -- | -- | -- | -- |
Neuroblast division | GO:0055057 | 0.0795144 | 2 | 0.0412241 | FGFR2 LRP6 | -- | -- | -- | -- | -- | -- |
Forebrain neuroblast division | GO:0021873 | 0.0795144 | 2 | 0.0412241 | FGFR2 LRP6 | -- | -- | -- | -- | -- | -- |
Generation of neurons | GO:0048699 | 112.797 | 31 | 0.000188727 | ONECUT2 ANK3 CACNB3 CDK6 CELSR3 FGFR2 MEF2A NFIB PICALM PLAG1 PLXNA1 PSD4 PTPRR RAB11A RPS6KA4 SIX4 COL4A4 DFNB31 DISC1 SRF STX3 ADCY1 CDKN1C CNP ENAH HOXC10 LIF LRP6 ROCK1 RPS6KA3 TFAP2A | -- | DISC1 | -- | -- | DISC1 | -- |
Cell morphogenesis involved in neuron differentiation | GO:0048667 | 616.805 | 15 | 0.0366659 | ANK3 CACNB3 CELSR3 FGFR2 MEF2A NFIB PICALM PLXNA1 RPS6KA4 COL4A4 ADCY1 CNP ENAH ROCK1 RPS6KA3 | -- | -- | -- | -- | -- | -- |