Figure 5
From: jMOSAiCS: joint analysis of multiple ChIP-seq datasets
Computational experiments comparing jMOSAiCS with the separate analysis approach on data simulated from MeCP2 ChIP-seq data. Comparison of dataset-specific region-level enrichment detection (E2) by jMOSAiCS and separate analysis on replicate 2 for which the number of data lanes varies. jMOSAiCS (x-y) and Separate (x-y) refer to jMOSAiCS and separate analysis of x lanes of replicate 1 with y lanes of replicate 2. (a) Proportion of top ranking enriched regions that are true positives. (b) Sensitivity by nominal FDR. (c) Observed FDR by nominal FDR. ChIP: chromatin immunoprecipitation; FDR: false discovery rate; jMOSAiCS: joint model-based one- and two-sample analysis and inference for ChIP-seq