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Table 1 Summary of murine models studied

From: Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts

A. B.
Tumor model Strain Promoter Transgene Reference Primarily found in murine class(es): Intramodel variation
Brg1 +/- Mixed   Brg1 heterozygous [7] Squamous-likeEx (4/12); Erbb2-likeEx (3/12); 3 others Heterogeneous
Normal mammary-lactating FVB   Normal lactating mammary tissue   Normal-likeEx (2/2) Homogeneous
p18 -/- BALB/c   p18 homozygous null [8] Erbb2-likeEx (5/9); Normal-likeEx (2/9); Squamous-likeEx (1/9) Heterogeneous
Pik3ca-H1047R FVB MMTV Pik3ca H1047R mutation overexpression [9] Class14Ex (5/12); Squamous-likeEx (5/12); 2 others Semi-homogeneous
Rb -/- Mixed   Rb homozygous null [10] Erbb2-likeEx (4/10); NeuEx (1/10); 3 others Heterogeneous
Stat1 -/- C57BL/6J   Stat1 homozygous null [11] Stat1Ex (7/7) Homogeneous
TgMMTV-Aib1 FVB MMTV Aib1 overexpression [12] Erbb2-likeEx (4/9); MycEx (2/9); 2 others Heterogeneous
TgMMTV-Atx FVB MMTV Atx overexpression [13] Class14Ex (3/5); Squamous-likeEx (1/5); 1 other Semi-homogeneous
TgMMTV-Fgf3 FVB MMTV Fgf3 overexpression [14] Erbb2-likeEx (2/5); Normal-likeEx (2/5); Wnt1-LateEx (1/5) Semi-homogeneous
TgMMTV-Hras FVB MMTV Hras overexpression [15] NeuEx (5/8); Class8Ex (2/8) Semi-homogeneous
TgMMTV-Lpa FVB MMTV Lpa1, Lpa2, or Lpa3 overexpression [12] Normal-likeEx (6/15); Claudin-lowEx (3/15); 3 others Heterogeneous
TgMMTV-Myc FVB MMTV cMyc overexpression [15] MycEx (4/5); Class8Ex (1/5) Homogeneous
TgMMTV-Wnt1,iFgfr FVB MMTV Wnt1 overexpression, inducible Fgfr1 or Fgfr2 [16] Wnt1-EarlyEx (7/12) Homogeneous
TgWAPCre-Etv6 Mixed WAP Etv6-Ntrk3 fusion gene overexpression [17] Erbb2-likeEx (12/12) Homogeneous
Brca1+/-, Trp53+/-, irradiated BALB/c   Brca1 and Trp53 heterozygous, irradiated [18] p53null-BasalEx (6/7); Wnt1-EarlyEx (1/7) Homogeneous
DMBA-induced FVB   DMBA treated [19] Squamous-likeEx (4/11); Claudin-lowEx (3/11); 3 others Heterogeneous
Normal mammary Mixed   Normal mammary tissue   Normal-likeEx (16/16) Homogeneous
TgC3(1)-Tag FVB C3(1) SV40 large T antigen [20] C3TagEx (28/30); Claudin-lowEx (2/30) Homogeneous
TgMMTV-Cre Brca1Co/Co, Trp53+/- C57BL/6J MMTV Brca1 flox, Trp53 heterozygous [21] p53null-BasalEx (4/10); Claudin-lowEx (3/10); 1 other Heterogeneous
TgMMTV-Neu FVB MMTV Rat Her2 overexpression [22] NeuEx (25/28); Normal-likeEx (2/28); 1 other Homogeneous
TgMMTV-PyMT FVB MMTV Py-MT overexpression [23] PyMTEx (9/17); Class3Ex (1/17) Homogeneous
TgMMTV-Wnt1 FVB MMTV Wnt1 overexpression [24] Wnt1-EarlyEx (15/25); Wnt1-LateEx (7/25); 3 others Semi-homogeneous
TgWAP-Int3 FVB WAP Notch4 overexpression [25] WapINT3Ex (6/7); Class3Ex (1/7) Homogeneous
TgWAP-Myc FVB WAP cMyc overexpression [26] MycEx (18/21); Class8Ex (3/21) Homogeneous
TgWAP-T121 Mixed WAP pRb, p107, p130 inactivation [27] Erbb2-likeEx (3/6); Class3Ex (2/6); Claudin-lowEx (1/6) Semi-homogeneous
TgWAP-T121, Trp53+/- B6D2F1 WAP pRb, p107, p130 inactivation, Trp53het [27] C3TagEx (1/1)  
TgWAP-Tag C57BL/6J WAP SV40 large T antigen [28] C3TagEx (4/4) Homogeneous
Trp53 -/- BALB/c   Trp53 homozygous null [29] p53null-LuminalEx (27/58); p53null-BasalEx (15/58); 5 others Heterogeneous
Trp53+/-, irradiated BALB/c   Trp53 heterozygous, irradiated [30] p53null-BasalEx (4/8); Claudin-lowEx (2/8); 2 others Heterogeneous
  1. A complete list of all GEMMs used. The bottom 15 models/normal mammary were studied by Herschkowitz et al.[31]. C3(1), 5' flanking region of the C3(1) component of the rat prostate steroid binding protein. MMTV, mouse mammary tumor virus. WAP, whey acidic protein.