Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts

Pfefferle, Adam D; Herschkowitz, Jason I; Usary, Jerry; Harrell, Joshua Chuck; Spike, Benjamin T; Adams, Jessica R; Torres-Arzayus, Maria I; Brown, Myles; Egan, Sean E; Wahl, Geoffrey M; Rosen, Jeffrey M; Perou, Charles M

doi:10.1186/gb-2013-14-11-r125

Table 1 Summary of murine models studied

From: Transcriptomic classification of genetically engineered mouse models of breast cancer identifies human subtype counterparts

A.					B.
Tumor model	Strain	Promoter	Transgene	Reference	Primarily found in murine class(es):	Intramodel variation
Brg1 ^+/-	Mixed		Brg1 heterozygous	[7]	Squamous-like^Ex (4/12); Erbb2-like^Ex (3/12); 3 others	Heterogeneous
Normal mammary-lactating	FVB		Normal lactating mammary tissue		Normal-like^Ex (2/2)	Homogeneous
p18 ^-/-	BALB/c		p18 homozygous null	[8]	Erbb2-like^Ex (5/9); Normal-like^Ex (2/9); Squamous-like^Ex (1/9)	Heterogeneous
Pik3ca-H1047R	FVB	MMTV	Pik3ca H1047R mutation overexpression	[9]	Class14^Ex (5/12); Squamous-like^Ex (5/12); 2 others	Semi-homogeneous
Rb ^-/-	Mixed		Rb homozygous null	[10]	Erbb2-like^Ex (4/10); Neu^Ex (1/10); 3 others	Heterogeneous
Stat1 ^-/-	C57BL/6J		Stat1 homozygous null	[11]	Stat1^Ex (7/7)	Homogeneous
TgMMTV-Aib1	FVB	MMTV	Aib1 overexpression	[12]	Erbb2-like^Ex (4/9); Myc^Ex (2/9); 2 others	Heterogeneous
TgMMTV-Atx	FVB	MMTV	Atx overexpression	[13]	Class14^Ex (3/5); Squamous-like^Ex (1/5); 1 other	Semi-homogeneous
TgMMTV-Fgf3	FVB	MMTV	Fgf3 overexpression	[14]	Erbb2-like^Ex (2/5); Normal-like^Ex (2/5); Wnt1-Late^Ex (1/5)	Semi-homogeneous
TgMMTV-Hras	FVB	MMTV	Hras overexpression	[15]	Neu^Ex (5/8); Class8^Ex (2/8)	Semi-homogeneous
TgMMTV-Lpa	FVB	MMTV	Lpa1, Lpa2, or Lpa3 overexpression	[12]	Normal-like^Ex (6/15); Claudin-low^Ex (3/15); 3 others	Heterogeneous
TgMMTV-Myc	FVB	MMTV	cMyc overexpression	[15]	Myc^Ex (4/5); Class8^Ex (1/5)	Homogeneous
TgMMTV-Wnt1,iFgfr	FVB	MMTV	Wnt1 overexpression, inducible Fgfr1 or Fgfr2	[16]	Wnt1-Early^Ex (7/12)	Homogeneous
TgWAPCre-Etv6	Mixed	WAP	Etv6-Ntrk3 fusion gene overexpression	[17]	Erbb2-like^Ex (12/12)	Homogeneous
Brca1^+/-, Trp53^+/-, irradiated	BALB/c		Brca1 and Trp53 heterozygous, irradiated	[18]	p53null-Basal^Ex (6/7); Wnt1-Early^Ex (1/7)	Homogeneous
DMBA-induced	FVB		DMBA treated	[19]	Squamous-like^Ex (4/11); Claudin-low^Ex (3/11); 3 others	Heterogeneous
Normal mammary	Mixed		Normal mammary tissue		Normal-like^Ex (16/16)	Homogeneous
TgC3(1)-Tag	FVB	C3(1)	SV40 large T antigen	[20]	C3Tag^Ex (28/30); Claudin-low^Ex (2/30)	Homogeneous
TgMMTV-Cre Brca1^Co/Co, Trp53^+/-	C57BL/6J	MMTV	Brca1 flox, Trp53 heterozygous	[21]	p53null-Basal^Ex (4/10); Claudin-low^Ex (3/10); 1 other	Heterogeneous
TgMMTV-Neu	FVB	MMTV	Rat Her2 overexpression	[22]	Neu^Ex (25/28); Normal-like^Ex (2/28); 1 other	Homogeneous
TgMMTV-PyMT	FVB	MMTV	Py-MT overexpression	[23]	PyMT^Ex (9/17); Class3^Ex (1/17)	Homogeneous
TgMMTV-Wnt1	FVB	MMTV	Wnt1 overexpression	[24]	Wnt1-Early^Ex (15/25); Wnt1-Late^Ex (7/25); 3 others	Semi-homogeneous
TgWAP-Int3	FVB	WAP	Notch4 overexpression	[25]	WapINT3^Ex (6/7); Class3^Ex (1/7)	Homogeneous
TgWAP-Myc	FVB	WAP	cMyc overexpression	[26]	Myc^Ex (18/21); Class8^Ex (3/21)	Homogeneous
TgWAP-T121	Mixed	WAP	pRb, p107, p130 inactivation	[27]	Erbb2-like^Ex (3/6); Class3^Ex (2/6); Claudin-low^Ex (1/6)	Semi-homogeneous
TgWAP-T121, Trp53^+/-	B6D2F1	WAP	pRb, p107, p130 inactivation, Trp53het	[27]	C3Tag^Ex (1/1)
TgWAP-Tag	C57BL/6J	WAP	SV40 large T antigen	[28]	C3Tag^Ex (4/4)	Homogeneous
Trp53 ^-/-	BALB/c		Trp53 homozygous null	[29]	p53null-Luminal^Ex (27/58); p53null-Basal^Ex (15/58); 5 others	Heterogeneous
Trp53^+/-, irradiated	BALB/c		Trp53 heterozygous, irradiated	[30]	p53null-Basal^Ex (4/8); Claudin-low^Ex (2/8); 2 others	Heterogeneous

A complete list of all GEMMs used. The bottom 15 models/normal mammary were studied by Herschkowitz et al.[31]. C3(1), 5' flanking region of the C3(1) component of the rat prostate steroid binding protein. MMTV, mouse mammary tumor virus. WAP, whey acidic protein.

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