Figure 2
From: The genetic heterogeneity and mutational burden of engineered melanomas in zebrafish models
Overview of substitutions. (A) The number of substitutions (dark blue columns) and indels (red columns) per sample, corresponding to their initiating germline mutations (bottom shaded). For p53, light blue indicates p53+/- and dark blue p53-/-. Asterisk specifies mitf:MITF expression in a mitf -/- background. (B-E) Mutation spectrum of all and selected samples. For all samples (B) mutations are indicated on the transcribed (T) and untranscribed (UT) strand. (F) Evidence of kataegis within 4,500 bp region in ZD8a, a BRAF;p53 mutant sample. Somatic mutations are highlighted with colored circles corresponding to the type of substitution.