Figure 1

Pairwise scatter plots for luciferase signals. Plotted is |log₂(I_MT/I_WT)|, where I_MT and I_WT are the mutant and wild-type normalized luminosities, respectively, in four cell lines (K562, HCT116, HT1080 and HepG2). Experiments plotted are those where TFBS function was validated in all four cell lines (bullet), three cell lines (open circle with middle dot), two cell lines (open square with middle dot) and one cell line (cross). The Spearman correlation coefficients for experiments carried out in K562 cells with those in HCT116 cells (a), HT1080 cells (b), and HepG2 cells (c) are 0.57, 0.64 and 0.65, respectively.