Predicted interfaces are enriched for SNPs in the Coev2Net predicted high-confidence MAPK network. (a) Relative distribution of PolyPhen annotated mutations at the interface and non-interface. (b) SNP (PolyPhen annotated) prevalence at the interface and non-interface. (c) Somatic mutations characterized as 'missense' preferentially fall on the interface (bottom). The white circles represent corresponding means. Error bars represent the 75% to 25% data range.