Skip to main content
Figure 4 | Genome Biology

Figure 4

From: The mouse DXZ4 homolog retains Ctcf binding and proximity to Pls3 despite substantial organizational differences compared to the primate macrosatellite

Figure 4

DNA methylation of elements in the vicinity of Dxz4. (a) Schematic map of the region encompassing Dxz4 and the downstream satellite repeat (diverging open arrows). Left-pointing arrows represent Dxz4, and the location of the Dxz4 promoter and CGI are indicated. The red boxes indicate regions assessed for DNA methylation by PCR of bisulfite-modified DNA, cloning, and sequencing. The location of bisulfite analysis within the Dxz4 array is shown for a single monomer immediately below the array. (b) Cytosine methylation at CpG dinucleotides for the five regions shown in (a). Data are given for two independent males (top) and two independent females (bottom). Methylated cytosine is represented by a black circle whereas unmethylated is represented by an open circle. DNA variants that result in a sequence that is no longer a CpG are represented by dashes. Each row of circles represents DNA sequence obtained from a single clone, and each set of data consists of at least nine independent clones.

Back to article page

Genome Biology

ISSN: 1474-760X

Contact us