Table 1 Pearson correlations between features and negative genetic interaction degree in S. pombe (pom) and S. cerevisiae (cer) are observed to be significant in many cases

From: Conserved rules govern genetic interaction degree across species

	Pearson's r	P-value	95% CI
SM fitness defect
pom	0.48	9.90E-31	[0.41, 0.54]
cer	0.75	0.00E+00	[0.77, 0.74]
Multifunctionality
pom	0.3	1.01E-12	[0.22, 0.37]
cer	0.26	4.52E-53	[0.29, 0.23]
Conservation
pom	0.07	1.06E-01	[-0.01, 0.15]
cer	0.16	7.11E-21	[0.19, 0.13]
Broad conservation
pom	0	9.30E-01	[-0.09, 0.08]
cer	0.16	9.90E-19	[0.19, 0.12]
PPI degree
pom	0.2	5.84E-03	[0.06, 0.33]
cer	0.15	1.49E-19	[0.19, 0.12]
Expression level
pom	-0.05	2.42E-01	[-0.13, 0.03]
cer	0.11	7.40E-10	[0.14, 0.08]
Disorder
pom	0.13	3.05E-03	[0.04, 0.21]
cer	0.11	1.91E-10	[0.14, 0.08]
Codon Adaptation Index
pom	-0.02	6.49E-01	[-0.1, 0.06]
cer	0.09	1.91E-07	[0.12, 0.06]
Protein length
pom	0	9.18E-01	[-0.08, 0.09]
cer	0.05	3.57E-03	[0.08, 0.02]
Co-expression degree
pom	0	9.38E-01	[-0.08, 0.09]
cer	0.05	3.75E-03	[0.08, 0.02]
Number of domains
pom	-0.01	7.37E-01	[-0.1, 0.07]
cer	0.01	4.54E-01	[0.05, -0.02]
Number of unique domains
pom	-0.02	6.86E-01	[-0.1, 0.07]
cer	0.01	6.98E-01	[0.04, -0.03]
Nc
pom	-0.01	7.56E-01	[-0.1, 0.07]
cer	-0.08	2.95E-06	[-0.05, -0.11]
dN/dS
pom	-0.05	2.48E-01	[-0.14, 0.04]
cer	-0.11	1.58E-09	[-0.07, -0.14]
Copy number
pom	-0.08	5.26E-02	[-0.17, 0]
cer	-0.12	1.01E-11	[-0.08, -0.15]
Expression variation
pom	-0.15	4.11E-04	[-0.23, -0.07]
cer	-0.18	3.87E-27	[-0.15, -0.21]

CI, confidence interval; PPI, protein-protein interaction; SM, single mutant

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