Figure 3

Similarity of core SuMs of different diseases and enrichment of disease genes in the union of core SuMs. (a) Heatmap showing that core SuMs are more similar than SuMs. The color intensity represents similarity, defined by computing the ratio between the number of genes shared by two SuMs and the total number of genes in the two SuMs (Jaccard similarity index). (b) In an extended analysis of GWAS genes of 145 other diseases, the union of the core SuMs was enriched with GWAS genes. This enrichment increased with disease gene pleiotropy. CLL,.