Figure 1

Overview of identification of susceptibility modules (SuMs). (a) Maximal cliques were obtained from a human PPI. (b) Disease-associated cliques were identified by selecting those that were enriched for differentially expressed genes. (c) Such cliques were mapped onto the PPI network, resulting in the identification of a SuM of overlapping cliques. (d) A core SuM was identified using average shortest path length. (e) This core SuM was validated by showing enrichment for GWAS genes.