Nested subnetworks. Genes differentially expressed in estrogen-treated MCF-7 cells at 3, 6 or 12 h (relative to 0 h; Carroll et al.  dataset) were mapped to the human interactome (HPRD database ) and for each time point the largest subnetwork was selected in order to demonstrate how RedeR represents nested structures (additional details in Figure 5). Node coloring depicts differential expression as log2 fold-change (logFC). The insets correspond to the overlap between consecutive time points.