Table 1 Comparison of MZT in the soma versus the PGCs
From: Genome-wide analysis of the maternal-to-zygotic transition in Drosophila primordial germ cells
| Â | Soma | Primordial germ cells | ||
|---|---|---|---|---|
RNA decay | Â | Â | Â | Â |
   Material analyzed | Unfertilized egg [3] | Embryo [69] | PGCs (this study) | PGCs (this study) |
   Time | 2-to-4 hours, 4-to-6 hours versus 0-to-2 hours | 2-to-3 hours versus 0-to-1 hours | 3-to-5 hours versus 1-to-3 hours | 5-to-7 hours versus 3-to-5 hours |
   Gene numbers | 1,637 | 2,107 | 810 | 506 |
   Genes dependent on Smaug for RNA decay | 975 (60% of RNA decay) | NA | 301 (37% of RNA decay) | 142 (28% of RNA decay) |
   SREs in RNAs expressed | 48% | 46% | 45% | 45% |
   SREs in RNA decay | 59% | 63% | 52% | 56% |
   SREs in Smaug-dependent RNA decay | 67% | NA | 61% | 54% |
   GO terms for RNA decay | Transmembrane transport Proteasome DNA damage/repair Alternative splicing Cell/developmental maturation Nucleotide-binding | Nucleotide-binding Metabolism germ cell Development Alternative splicing Sexual reproduction | Intrinsic/integral to membrane EGF-like domain Ras/Ras GTPase N-linked glycosylation Pole plasm RNA localization Pole plasm assembly Embryonic axis specification Alternative splicing | Intrinsic/integral to membrane Dephosphorylation Lipid catabolism Alternative splicing |
   GO terms for Smaug-dependent RNA decay | Cell cycle phosphoprotein Nucleotide-binding Microtubule-based process Chromosome organization Proteasome | NA | Alternative splicing Developmental protein Cell surface receptor-linked signal transduction | Electron carrier activity |
Zygotic transcription | Â | Â | Â | Â |
   Material analyzed | Embryo [69] | Embryo [12] | PGCs (this study) | PGCs (this study) |
   Time | 0-to-1 hours versus 1-to-2 hours | 2-to-3 hours versus stage 14 oocytes | 3-to-5 hours versus 1-to-3 hours | 5-to-7 hours versus 3-to-5 hours |
   Gene numbers | 1,110 | 939 | 657 | 167 |
   Genes dependent on Smaug for zygotic transcription | NA | 371 (40%) | 248 (38%) | 50 (30%) |
   SREs in zygotic transcription | 54% | 48% | 35% | 43% |
   SREs in Smaug-dependent zygotic transcription | NA | 36% | 29% | 30% |
   GO terms for zygotic transcription | Transcription Morphogenesis Interphase Development | Developmental protein Morphogenesis transcription Metabolism | Structural constituent of ribosome Structural constituent of mitochondrial ribosome Mitochondrial membrane part mitochondrial electron transport Transcriptional regulator activity | Casein kinase II mitotic spindle organization |
   GO terms for Smaug-dependent zygotic transcription | NA | Morphogenesis Signal Cell fate | No significant GO terms | No significant GO terms |