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Table 1 Comparison of MZT in the soma versus the PGCs

From: Genome-wide analysis of the maternal-to-zygotic transition in Drosophila primordial germ cells

  Soma Primordial germ cells
RNA decay     
   Material analyzed Unfertilized egg [3] Embryo [69] PGCs (this study) PGCs (this study)
   Time 2-to-4 hours, 4-to-6 hours versus 0-to-2 hours 2-to-3 hours versus 0-to-1 hours 3-to-5 hours versus 1-to-3 hours 5-to-7 hours versus 3-to-5 hours
   Gene numbers 1,637 2,107 810 506
   Genes dependent on Smaug for RNA decay 975 (60% of RNA decay) NA 301 (37% of RNA decay) 142 (28% of RNA decay)
   SREs in RNAs expressed 48% 46% 45% 45%
   SREs in RNA decay 59% 63% 52% 56%
   SREs in Smaug-dependent RNA decay 67% NA 61% 54%
   GO terms for RNA decay Transmembrane transport Proteasome
DNA damage/repair
Alternative splicing
Cell/developmental maturation
Metabolism germ cell
Alternative splicing
Sexual reproduction
Intrinsic/integral to membrane
EGF-like domain
Ras/Ras GTPase
N-linked glycosylation
Pole plasm
RNA localization
Pole plasm assembly
Embryonic axis specification
Alternative splicing
Intrinsic/integral to membrane
Lipid catabolism
Alternative splicing
   GO terms for Smaug-dependent RNA decay Cell cycle phosphoprotein
Microtubule-based process
Chromosome organization
NA Alternative splicing
Developmental protein
Cell surface receptor-linked signal transduction
Electron carrier activity
Zygotic transcription     
   Material analyzed Embryo [69] Embryo [12] PGCs (this study) PGCs (this study)
   Time 0-to-1 hours versus 1-to-2 hours 2-to-3 hours versus stage 14 oocytes 3-to-5 hours versus 1-to-3 hours 5-to-7 hours versus 3-to-5 hours
   Gene numbers 1,110 939 657 167
   Genes dependent on Smaug for zygotic transcription NA 371 (40%) 248 (38%) 50 (30%)
   SREs in zygotic transcription 54% 48% 35% 43%
   SREs in Smaug-dependent zygotic transcription NA 36% 29% 30%
   GO terms for zygotic transcription Transcription
Developmental protein
Morphogenesis transcription
Structural constituent of ribosome
Structural constituent of mitochondrial ribosome
Mitochondrial membrane part mitochondrial electron transport
Transcriptional regulator activity
Casein kinase II mitotic spindle organization
   GO terms for Smaug-dependent zygotic transcription NA Morphogenesis
Cell fate
No significant GO terms No significant GO terms
  1. NA, not available since smaug mutants were not analyzed.